MicroRNA-30c attenuates fibrosis progression and vascular dysfunction in systemic sclerosis model mice

Systemic sclerosis (SSc) is characterized by peripheral circulatory disturbance and fibrosis in skin visceral organs. We recently demonstrated that ?2-antiplasmin (?2AP) elevated SSc dermal fibroblasts model mice, associated with progression vascular dysfunction. In the present study, we predicted ?2AP could be a target of microRNA-30c (miR-30c) using TargetScan online database, investigated effect miR-30c on pathogenesis bleomycin-induced mice. attenuated expression, prevented pro-fibrotic changes (increased thickness, collagen deposition, myofibroblast accmulation) dysfunction (the reduction endothelial cells (ECs) blood flow) Furthermore, suppressed pulmonary exerts anti-fibrotic anti-angiopathy effects might provide basis for clinical strategies SSc.